Public Health Research Institute Center
New Jersey Medical School - Rutgers, The State University of New Jersey
225 Warren Street, Rm W250.Q
Newark, New Jersey 07103
Phone: (973) 854-3226
Dr. Subbian’s expertise encompasses studies of human disease and animal models to better understand host immune responses in the pathogenesis of mycobacterial infections. The major research activities in the lab are focused towards understanding the host-pathogen interactions in active tuberculosis (TB) and latent infection (LTBI) and determining the host immunological determinants that are responsible for the progression of Mycobacterium tuberculosis (Mtb) infection to active TB disease versus LTBI using in vitro (primary cells and cell lines of human and murine origin) and in vivo (mice and rabbit) models of infection with clinical isolates of Mtb. His group has characterized the kinetics of disease progression (active TB) or control of infection (LTBI) in rabbit lungs using histological, immunological and genome-wide transcriptional profiling. They have delineated the early differences in the host immunological profile in rabbit lung that determines the diverse outcome following infection, and compared the differences in immunopathology between active TB and LTBI throughout the course of infection. Other areas of active research include exploring the possibilities of host-directed, adjunctive immune modulation as an intervention to improve current TB treatment with antibiotics.
Ayyappan JP, Vinnard C, Subbian S, Nagajyothi JF (2018) Effect of Mycobacterium tuberculosis infection on adipocyte physiology. Microbes Infect 20: 81-88. PMI: 29109018
Dehnad A, Ravindran R, Subbian S, Khan IH (2016) Development of immune-biomarkers of pulmonary tuberculosis in a rabbit model. Tuberculosis (Edinb) 101: 1-7. PMI: 27865378
Dusthackeer A, Kumar V, Subbian S, Sivaramakrishnan G, Zhu G, Subramanyam B, Hassan S, Nagamaiah S, Chan J, Paranji Rama N (2008) Construction and evaluation of luciferase reporter phages for the detection of active and non-replicating tubercle bacilli. J Microbiol Methods 73: 18-25. PMI: 18272245
Guerrini V, Subbian S, Santucci P, Canaan S, Gennaro ML, Pozzi G (2016) Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage. PLoS One 11: e0167989. PMI: 27959952
Kolloli A, Subbian S (2017) Host-Directed Therapeutic Strategies for Tuberculosis. Front Med (Lausanne) 4: 171. PMI: 29094039
Koo MS, Subbian S, Kaplan G (2012) Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. Cell Commun Signal 10: 2. PMI: 22280836
Kurthkoti K, Amin H, Marakalala MJ, Ghanny S, Subbian S, Sakatos A, Livny J, Fortune SM, Berney M, Rodriguez GM (2017) The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas. MBio 8. PMI: 28811344
Liu TB, Subbian S, Pan W, Eugenin E, Xie J, Xue C (2014) Cryptococcus inositol utilization modulates the host protective immune response during brain infection. Cell Commun Signal 12: 51. PMI: 25201772
Manca C, Koo MS, Peixoto B, Fallows D, Kaplan G, Subbian S (2013) Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection. PLoS One 8: e74082. PMI: 24015316
Park B, Subbian S, El-Etr SH, Cirillo SL, Cirillo JD (2008) Use of gene dosage effects for a whole-genome screen to identify Mycobacterium marinum macrophage infection loci. Infect Immun 76: 3100-3115. PMI: 18443095
Shi L, Eugenin EA, Subbian S (2016) Immunometabolism in Tuberculosis. Front Immunol 7: 150. PMI: 27148269
Subbian S, Bandyopadhyay N, Tsenova L, O'Brien P, Khetani V, Kushner NL, Peixoto B, Soteropoulos P, Bader JS, Karakousis PC, Fallows D, Kaplan G (2013) Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits. Cell Commun Signal 11: 60. PMI: 23958185
Subbian S, Mehta PK, Cirillo SL, Bermudez LE, Cirillo JD (2007) A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species. Infect Immun 75: 127-134. PMI: 17030568
Subbian S, Narayanan S (2007) Identification and characterization of the regulatory elements of the inducible acetamidase operon from Mycobacterium smegmatis. Can J Microbiol 53: 599-606. PMI: 17668018
Subbian S, Pandey R, Soteropoulos P, Rodriguez GM (2015) Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis. J Immunol Res 2015: 385402. PMI: 26339659
Subbian S, Tsenova L, Holloway J, Peixoto B, O'Brien P, Dartois V, Khetani V, Zeldis JB, Kaplan G (2016) Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model. EBioMedicine 4: 104-114. PMI: 26981575
Subbian S, Tsenova L, Kim MJ, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, Russell DG, Kaplan G (2015) Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study. PLoS One 10: e0132249. PMI: 26133981
Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Dartois V, Muller G, Kaplan G (2011) Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog 7: e1002262. PMI: 21949656
Subbian S, Tsenova L, O'Brien P, Yang G, Kushner NL, Parsons S, Peixoto B, Fallows D, Kaplan G (2012) Spontaneous latency in a rabbit model of pulmonary tuberculosis. Am J Pathol 181: 1711-1724. PMI: 22960076
Subbian S, Tsenova L, Yang G, O'Brien P, Parsons S, Peixoto B, Taylor L, Fallows D, Kaplan G (2011) Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response. Open Biol 1: 110016. PMI: 22645653
Tasker C, Subbian S, Gao P, Couret J, Levine C, Ghanny S, Soteropoulos P, Zhao X, Landau N, Lu W, Chang TL (2016) IFN-epsilon protects primary macrophages against HIV infection. JCI Insight 1: e88255. PMI: 27942584
Tsenova L, O'Brien P, Holloway J, Peixoto B, Soteropoulos P, Fallows D, Kaplan G, Subbian S (2014) Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosis. J Interferon Cytokine Res 34: 716-726. PMI: 24831609
BSc (Biochemistry), Bharathiyar University Coimbatore, India. 1990-1993.
MSc (Biomedical Genetics), University of Madras, Chennai, India. 1993-1995.
Ph.D (Basic Medical Sciences), Tuberculosis Research Center, Chennai, India. 1996-2003.
Postdoctoral Fellow, Dept. of Veterinary and Basic Sciences, University of Nebraska, Lincoln, NE. 2003 – 2005.
Postdoctoral Research Associate, Dept. of Microbial and Molecular Pathogenesis, Texas AM Health Science Center, College Station, TX. 2005 – 2008.
Research Teaching Specialist, Lab. of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center at Univ. of Medical and Dentistry of New Jersey, NJ. 2008 – 2013.