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Scientific Overview Research Interest Summary Principal Investigators Emeritus Faculty Recent Publications
Recent Published Work By PHRI Faculty

Vargas DY, Kramer FR, Tyagi S, Marras SAE (2016) Multiplex real-time PCR assays that measure the abundance of extremely rare mutations associated with cancer. PLoS ONE 11: e0156546. PMI: 27244445

Zhao Y, Paderu P, Delmas G, Dolgov E, Lee MH, Senter M, Park S, Leivers S, Perlin DS (2015) Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. J Trauma Acute Care Surg 79: S121-129. PMI: 26406424

Xiong H, Carter RA, Leiner IM, Tang YW, Chen L, Kreiswirth BN, Pamer EG (2015) Distinct Contributions of Neutrophils and CCR2+ Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains. Infect Immun 83: 3418-3427. PMI: 26056382

Wang SH, Stevenson KB, Hines L, Mediavilla JR, Khan Y, Soni R, Dutch W, Brandt E, Bannerman T, Kreiswirth BN, Pancholi P, Prevention Epicenter Program of the Centers for Disease C, Prevention (2015) Evaluation of repetitive element polymerase chain reaction for surveillance of methicillin-resistant Staphylococcus aureus at a large academic medical center and community hospitals. Diagn Microbiol Infect Dis 81: 13-17. PMI: 25439582

Wang SH, Hines L, van Balen J, Mediavilla JR, Pan X, Hoet AE, Kreiswirth BN, Pancholi P, Stevenson KB (2015) Molecular and clinical characteristics of hospital and community onset methicillin-resistant Staphylococcus aureus strains associated with bloodstream infections. J Clin Microbiol 53: 1599-1608. PMI: 25740776

Vir P, Arrigucci R, Lakehal K, Davidow AL, Pine R, Tyagi S, Bushkin Y, Lardizabal A, Gennaro ML (2015) Single-Cell Cytokine Gene Expression in Peripheral Blood Cells Correlates with Latent Tuberculosis Status. PLoS One 10: e0144904. PMI: 26658491

Via LE, Savic R, Weiner DM, Zimmerman MD, Prideaux B, Irwin SM, Lyon E, O'Brien P, Gopal P, Eum S, Lee M, Lanoix JP, Dutta NK, Shim T, Cho JS, Kim W, Karakousis PC, Lenaerts A, Nuermberger E, Barry CE, 3rd, Dartois V (2015) Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives. ACS Infect Dis 1: 203-214. PMI: 26086040

Via LE, England K, Weiner DM, Schimel D, Zimmerman MD, Dayao E, Chen RY, Dodd LE, Richardson M, Robbins KK, Cai Y, Hammoud D, Herscovitch P, Dartois V, Flynn JL, Barry CE, 3rd (2015) A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets. Antimicrob Agents Chemother 59: 4181-4189. PMI: 25941223

Verdugo D, Fallows D, Ahuja S, Schluger N, Kreiswirth B, Mathema B (2015) Epidemiologic Correlates of Pyrazinamide-Resistant Mycobacterium tuberculosis in New York City. Antimicrob Agents Chemother 59: 6140-6150. PMI: 26195530

Subbian S, Tsenova L, Kim MJ, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, Russell DG, Kaplan G (2015) Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study. PLoS One 10: e0132249. PMI: 26133981

Subbian S, Pandey R, Soteropoulos P, Rodriguez GM (2015) Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis. J Immunol Res 2015: 385402. PMI: 26339659

Stevaert A, Nurra S, Pala N, Carcelli M, Rogolino D, Shepard C, Domaoal RA, Kim B, Alfonso-Prieto M, Marras SA, Sechi M, Naesens L (2015) An Integrated Biological Approach to Guide the Development of Metal-Chelating Inhibitors of Influenza Virus PA Endonuclease. Molecular Pharmacology 87: 323-337. PMI: 25477342

Solorzano A, Foni E, Cordoba L, Baratelli M, Razzuoli E, Bilato D, Martin Del Burgo MA, Perlin DS, Martinez J, Martinez-Orellana P, Fraile L, Chiapponi C, Amadori M, Del Real G, Montoya M (2015) Cross-Species Infectivity of H3N8 Influenza Virus in an Experimental Infection in Swine. J Virol 89: 11190-11202. PMI: 26311894

Shor E, Perlin DS (2015) Coping with stress and the emergence of multidrug resistance in fungi. PLoS Pathog 11: e1004668. PMI: 25790300

Shor E, Chauhan N (2015) A case for two-component signaling systems as antifungal drug targets. PLoS Pathog 11: e1004632. PMI: 25723524

Shields RK, Nguyen MH, Potoski BA, Press EG, Chen L, Kreiswirth BN, Clarke LG, Eschenauer GA, Clancy CJ (2015) Doripenem MICs and ompK36 porin genotypes of sequence type 258, KPC-producing Klebsiella pneumoniae may predict responses to carbapenem-colistin combination therapy among patients with bacteremia. Antimicrob Agents Chemother 59: 1797-1801. PMI: 25534733

Shields RK, Clancy CJ, Hao B, Chen L, Press EG, Iovine NM, Kreiswirth BN, Nguyen MH (2015) Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum beta-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae. Antimicrob Agents Chemother 59: 5793-5797. PMI: 26169413

Shi L, Salamon H, Eugenin EA, Pine R, Cooper A, Gennaro ML (2015) Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs. Sci Rep 5: 18176. PMI: 26658723

Ren W, Ma Y, Yang L, Gettie A, Salas J, Russell K, Blanchard J, Davidow A, Pei Z, Chang TL, Cheng-Mayer C (2015) Fast disease progression in simian HIV-infected female macaque is accompanied by a robust local inflammatory innate immune and microbial response. AIDS 29: F1-8. PMI: 26035329

Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE, 3rd, Dartois V (2015) The association between sterilizing activity and drug distribution into tuberculosis lesions. Nat Med. PMI: 26343800

Prideaux B, ElNaggar MS, Zimmerman M, Wiseman JM, Li X, Dartois V (2015) Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling. Int J Mass Spectrom 377: 699-708. PMI: 26185484

Perlin DS, Shor E, Zhao Y (2015) Update on Antifungal Drug Resistance. Curr Clin Microbiol Rep 2: 84-95. PMI: 26120512

Perlin DS (2015) Mechanisms of echinocandin antifungal drug resistance. Ann N Y Acad Sci 1354: 1-11. PMI: 26190298

Perlin DS (2015) Echinocandin Resistance in Candida. Clin Infect Dis 61 Suppl 6: S612-617. PMI: 26567278

Patil S, Fribourg M, Ge Y, Batish M, Tyagi S, Hayot F, Sealfon SC (2015) Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-beta response to viral infection. Sci Signal 8: ra16. PMI: 25670204

Ocampo AM, Chen L, Cienfuegos AV, Roncancio G, Chavda KD, Kreiswirth BN, Jimenez JN (2015) High frequency of non-CG258 clones of carbapenem-resistant Klebsiella pneumoniae with distinct clinical characteristics: A two-year surveillance in five Colombian tertiary care hospitals. Antimicrob Agents Chemother. PMI: 26503660

Middelkoop K, Mathema B, Myer L, Shashkina E, Whitelaw A, Kaplan G, Kreiswirth B, Wood R, Bekker LG (2015) Transmission of tuberculosis in a South African community with a high prevalence of HIV infection. J Infect Dis 211: 53-61. PMI: 25053739

Mathema B, Lewis JJ, Connors J, Chihota VN, Shashkina E, van der Meulen M, Graviss EA, Ha NP, Kreiswirth BN, Grant AD, Fielding KL, Dorman SE, Churchyard GJ (2015) Molecular epidemiology of Mycobacterium tuberculosis among South African gold miners. Ann Am Thorac Soc 12: 12-20. PMI: 25419914

Lenaerts A, Barry CE, 3rd, Dartois V (2015) Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol Rev 264: 288-307. PMI: 25703567

Lakshminarayana SB, Huat TB, Ho PC, Manjunatha UH, Dartois V, Dick T, Rao SP (2015) Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents. J Antimicrob Chemother 70: 857-867. PMI: 25587994

LaBombardi VJ, Urban CM, Kreiswirth BN, Chen L, Osorio G, Kopacz J, Labaze G, Segal-Maurer S (2015) Evaluation of Remel Spectra CRE Agar for Detection of Carbapenem-Resistant Bacteria from Rectal Swabs Obtained from Residents of a Long-Term-Care Facility. J Clin Microbiol 53: 2823-2826. PMI: 26085613

Jensen RH, Astvad KM, Silva LV, Sanglard D, Jorgensen R, Nielsen KF, Mathiasen EG, Doroudian G, Perlin DS, Arendrup MC (2015) Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations. J Antimicrob Chemother 70: 2551-2555. PMI: 26017038

Ioannou P, Andrianaki A, Akoumianaki T, Kyrmizi I, Albert N, Perlin D, Samonis G, Kontoyiannis DP, Chamilos G (2015) Albumin enhances caspofungin activity against Aspergillus species by facilitating drug delivery to germinating hyphae. Antimicrob Agents Chemother. PMI: 26643329

Hu Y, Mathema B, Zhao Q, Chen L, Lu W, Wang W, Kreiswirth B, Xu B (2015) Acquisition of second-line drug resistance and extensive drug resistance during recent transmission of Mycobacterium tuberculosis in rural China. Clin Microbiol Infect 21: 1093 e1099-1093 e1018. PMI: 26348262

Evans SR, Hujer AM, Jiang H, Hujer KM, Hall T, Marzan C, Jacobs MR, Sampath R, Ecker DJ, Manca C, Chavda K, Zhang P, Fernandez H, Chen L, Mediavilla JR, Hill CB, Perez F, Caliendo AM, Fowler VG, Jr., Chambers HF, Kreiswirth BN, Bonomo RA, Antibacterial Resistance Leadership G (2015) Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II. Clin Infect Dis. PMI: 26409063

Espinel-Ingroff A, Alvarez-Fernandez M, Canton E, Carver PL, Chen SC, Eschenauer G, Getsinger DL, Gonzalez GM, Govender NP, Grancini A, Hanson KE, Kidd SE, Klinker K, Kubin CJ, Kus JV, Lockhart SR, Meletiadis J, Morris AJ, Pelaez T, Quindos G, Rodriguez-Iglesias M, Sanchez-Reus F, Shoham S, Wengenack NL, Borrell Sole N, Echeverria J, Esperalba J, Gomez GdlPE, Garcia Garcia I, Linares MJ, Marco F, Merino P, Peman J, Perez Del Molino L, Rosello Mayans E, Rubio Calvo C, Ruiz Perez de Pipaon M, Yague G, Garcia-Effron G, Guinea J, Perlin DS, Sanguinetti M, Shields R, Turnidge J (2015) Multicenter Study of Epidemiological Cutoff Values and Detection of Resistance in Candida spp. to Anidulafungin, Caspofungin, and Micafungin Using the Sensititre YeastOne Colorimetric Method. Antimicrob Agents Chemother 59: 6725-6732. PMI: 26282428

Dudiuk C, Gamarra S, Jimenez-Ortigosa C, Leonardelli F, Macedo D, Perlin DS, Garcia-Effron G (2015) Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans. J Clin Microbiol 53: 2037-2041. PMI: 25878347

Doman M, Kovacs R, Perlin DS, Kardos G, Gesztelyi R, Juhasz B, Bozo A, Majoros L (2015) Dose escalation studies with caspofungin against Candida glabrata. J Med Microbiol 64: 998-1007. PMI: 26296340

Ding J, Tasker C, Lespinasse P, Dai J, Fitzgerald-Bocarsly P, Lu W, Heller D, Chang TL (2015) Integrin alpha4beta7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism. J Acquir Immune Defic Syndr 69: 509-518. PMI: 26167616

DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhuo Z, Tonge PJ, Dannals RF, Holt DP, Lee CK, Weinstein EA, Dartois V, Dooley KE, Jain SK (2015) Determination of [11C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging. Antimicrob Agents Chemother 59: 5768-5774. PMI: 26169396

Datta P, Ravi J, Guerrini V, Chauhan R, Neiditch MB, Shell SS, Fortune SM, Hancioglu B, Igoshin OA, Gennaro ML (2015) The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions. Mol Microbiol 97: 408-422. PMI: 25899163

Cowen LE, Sanglard D, Howard SJ, Rogers PD, Perlin DS (2015) Mechanisms of Antifungal Drug Resistance. Cold Spring Harb Perspect Med 5: a019752. PMI: 25384768

Chen L, Peirano G, Lynch T, Chavda KD, Gregson DB, Church DL, Conly J, Kreiswirth BN, Pitout JD (2015) Molecular characterization using next generation sequencing of plasmids containing blaNDM-7 in Enterobacteriaceae from Calgary, Canada. Antimicrob Agents Chemother. PMI: 26643346

Chen L, Chavda KD, DeLeo FR, Bryant KA, Jacobs MR, Bonomo RA, Kreiswirth BN (2015) Genome Sequence of a Klebsiella pneumoniae Sequence Type 258 Isolate with Prophage-Encoded K. pneumoniae Carbapenemase. Genome Announc 3. PMI: 26089425

Chen L, Al Laham N, Chavda KD, Mediavilla JR, Jacobs MR, Bonomo RA, Kreiswirth BN (2015) First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine. Antimicrob Agents Chemother 59: 4305-4307. PMI: 25896692

Chavda KD, Chen L, Jacobs MR, Rojtman AD, Bonomo RA, Kreiswirth BN (2015) Complete sequence of a bla(KPC)-harboring cointegrate plasmid isolated from Escherichia coli. Antimicrob Agents Chemother 59: 2956-2959. PMI: 25753632

Chauhan N (2015) Two-Component Phosphorelays in Fungal Mitochondria and Beyond. Mitochondrion. PMI:

Bushkin Y, Radford F, Pine R, Lardizabal A, Mangura BT, Gennaro ML, Tyagi S (2015) Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry. Journal of immunology 194: 836-841. PMI: 25505292

Brinkworth AJ, Hammer CH, Olano LR, Kobayashi SD, Chen L, Kreiswirth BN, DeLeo FR (2015) Identification of Outer Membrane and Exoproteins of Carbapenem-Resistant Multilocus Sequence Type 258 Klebsiella pneumoniae. PLoS One 10: e0123219. PMI: 25893665

Bijlard M, Klunder B, de Jonge JC, Nomden A, Tyagi S, de Vries H, Hoekstra D, Baron W (2015) Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling. Mol Cell Biol 35: 675-687. PMI: 25512606

Bick MJ, Malik S, Mustaev A, Darst SA (2015) TFIIB is only approximately 9 A away from the 5'-end of a trimeric RNA primer in a functional RNA polymerase II preinitiation complex. PLoS One 10: e0119007. PMI: 25774659

Bayer AS, Mishra NN, Chen L, Kreiswirth BN, Rubio A, Yang SJ (2015) Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides. Antimicrob Agents Chemother 59: 4930-4937. PMI: 26055370

Bae B, Nayak D, Ray A, Mustaev A, Landick R, Darst SA (2015) CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc Natl Acad Sci U S A 112: E4178-4187. PMI: 26195788

Al Laham N, Mediavilla JR, Chen L, Abdelateef N, Elamreen FA, Ginocchio CC, Pierard D, Becker K, Kreiswirth BN (2015) MRSA clonal complex 22 strains harboring toxic shock syndrome toxin (TSST-1) are endemic in the primary hospital in Gaza, Palestine. PLoS One 10: e0120008. PMI: 25781188

Abdelhady W, Chen L, Bayer AS, Seidl K, Yeaman MR, Kreiswirth BN, Xiong YQ (2015) Early agr activation correlates with vancomycin treatment failure in multi-clonotype MRSA endovascular infections. J Antimicrob Chemother 70: 1443-1452. PMI: 25564565

Zolla-Pazner S, deCamp A, Gilbert PB, Williams C, Yates NL, Williams WT, Howington R, Fong Y, Morris DE, Soderberg KA, Irene C, Reichman C, Pinter A, Parks R, Pitisuttithum P, Kaewkungwal J, Rerks-Ngarm S, Nitayaphan S, Andrews C, O'Connell RJ, Yang ZY, Nabel GJ, Kim JH, Michael NL, Montefiori DC, Liao HX, Haynes BF, Tomaras GD (2014) Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection. PLoS One 9: e87572. PMI: 24504509

Zhou X, Zhao X, Xue C, Dai Y, Xu JR (2014) Bypassing both surface attachment and surface recognition requirements for appressorium formation by overactive ras signaling in Magnaporthe oryzae. Mol Plant Microbe Interact 27: 996-1004. PMI: 24835254

Zhao Y, Kontoyiannis DP, Roilides E, Walsh TJ, Perlin DS (2014) Reply to "detection of multiple fungal species in blood samples by real-time PCR: an interpretative challenge". J Clin Microbiol 52: 3517. PMI: 25143425

Zhao Y, Kontoyiannis DP, Roilides E, Walsh TJ, Perlin DS (2014) Reply to "not over yet: fungal infections following methyl prednisolone injections smoulder on". J Clin Microbiol 52: 3508. PMI: 25143421

Zhao Y, Armeanu E, DiVerniero R, Lewis TA, Dobson RC, Kontoyiannis DP, Roilides E, Walsh TJ, Perlin DS (2014) Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents. J Clin Microbiol 52: 2212-2215. PMI: 24719442

Zhao X, Hong Y, Drlica K (2014) Moving forward with ROS involvement in antimicrobial lethality. J Antimicrob Chemother (in press). PMI:

Zhao X, Drlica K (2014) Reactive oxygen species and the bacterial response to lethal stress. Curr Opin Microbiol 21C: 1-6. PMI: 25078317

Yates NL, Liao HX, Fong Y, deCamp A, Vandergrift NA, Williams WT, Alam SM, Ferrari G, Yang ZY, Seaton KE, Berman PW, Alpert MD, Evans DT, O'Connell RJ, Francis D, Sinangil F, Lee C, Nitayaphan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Pinter A, Zolla-Pazner S, Gilbert PB, Nabel GJ, Michael NL, Kim JH, Montefiori DC, Haynes BF, Tomaras GD (2014) Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Science translational medicine 6: 228ra239. PMI: 24648342

Xu S, Tyagi S, Schedl P (2014) Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2. PLoS Genet 10: e1004380. PMI: 24830287

Tsenova L, O'Brien P, Holloway J, Peixoto B, Soteropoulos P, Fallows D, Kaplan G, Subbian S (2014) Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosis. J Interferon Cytokine Res 34: 716-726. PMI: 24831609

Tasker C, Ding J, Schmolke M, Rivera-Medina A, Garcia-Sastre A, Chang TL (2014) 17beta-estradiol protects primary macrophages against HIV infection through induction of interferon-alpha. Viral Immunol 27: 140-150. PMI: 24801776

Subbian S, Eugenin E, Kaplan G (2014) Detection of Mycobacterium tuberculosis in latently infected lungs by immunohistochemistry and confocal microscopy. J Med Microbiol 63: 1432-1435. PMI: 25161200

Staab JF, Neofytos D, Rhee P, Jimenez-Ortigosa C, Zhang SX, Perlin DS, Marr KA (2014) Target enzyme mutations confer differential echinocandin susceptibilities in Candida kefyr. Antimicrob Agents Chemother. PMI: 24982083

Skerry C, Pinn ML, Bruiners N, Pine R, Gennaro ML, Karakousis PC (2014) Simvastatin increases the in vivo activity of the first-line tuberculosis regimen. J Antimicrob Chemother 69: 2453-2457. PMI: 24855121

Simitsopoulou M, Walsh TJ, Kyrpitzi D, Petraitis V, Kontoyiannis DP, Perlin DS, Roilides E (2014) Methylprednisolone impairs conidial phagocytosis but does not attenuate hyphal damage by neutrophils against Exserohilum rostratum. Med Mycol. PMI: 25056961

Shmelkov E, Krachmarov C, Grigoryan AV, Pinter A, Statnikov A, Cardozo T (2014) Computational prediction of neutralization epitopes targeted by human anti-V3 HIV monoclonal antibodies. PLoS One 9: e89987. PMI: 24587168

Shah AH, Singh A, Dhamgaye S, Chauhan N, Vandeputte P, Suneetha KJ, Kaur R, Mukherjee PK, Chandra J, Ghannoum MA, Sanglard D, Goswami SK, Prasad R (2014) Novel Role of a Family of Major Facilitator Transporters in Biofilm Development and Virulence of Candida albicans. Biochem J. PMI: 24621232

Salomon A, Krachmarov C, Lai Z, Honnen W, Zingman BS, Sarlo J, Gorny MK, Zolla-Pazner S, Robinson JE, Pinter A (2014) Specific sequences commonly found in the V3 domain of HIV-1 subtype C isolates affect the overall conformation of native Env and induce a neutralization-resistant phenotype independent of V1/V2 masking. Virology 448: 363-374. PMI: 24314667

Salas JT, Chang TL (2014) Microbiome in human immunodeficiency virus infection. Clin Lab Med 34: 733-745. PMI: 25439273

Salamon H, Bruiners N, Lakehal K, Shi L, Ravi J, Yamaguchi KD, Pine R, Gennaro ML (2014) Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection. Journal of immunology 193: 30-34. PMI: 24899504

Riou C, Gray CM, Lugongolo M, Gwala T, Kiravu A, Deniso P, Stewart-Isherwood L, Omar SV, Grobusch MP, Coetzee G, Conradie F, Ismail N, Kaplan G, Fallows D (2014) A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion. PLoS One 9: e102178. PMI: 25048802

Prideaux B, ElNaggar M, Zimmerman M, Wiseman J, Li X, Dartois V (2014) Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling. Int J Mass Spectrom: in press. PMI:

Prados-Rosales R, Weinrick BC, Pique DG, Jacobs WR, Jr., Casadevall A, Rodriguez GM (2014) Role for Mycobacterium tuberculosis Membrane Vesicles in Iron Acquisition. J Bacteriol 196: 1250-1256. PMI: 24415729

Perlin DS (2014) Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient management. Drugs 74: 1573-1585. PMI: 25255923

Pandey R, Rodriguez GM (2014) IdeR is required for iron homeostasis and virulence in Mycobacterium tuberculosis. Mol Microbiol 91: 98-109. PMI: 24205844

Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K (2014) Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. J Biol Chem 289: 12300-12312. PMI: 24497635

Monteiro AA, Pires RN, Baethgen LF, Carneiro LC, Tavares RG, Caierao J, Park S, Perlin DS, Rodrigues Filho EM, Pasqualotto AC (2014) Discrepancies among three laboratory methods for Clostridium difficile detection and a proposal for their optimal use. FEMS Microbiol Lett 350: 133-137. PMI: 24236508

Mekler V, Minakhin L, Borukhov S, Mustaev A, Severinov K (2014) Coupling of downstream RNA polymerase-promoter interactions with formation of catalytically competent transcription initiation complex. J Mol Biol. PMI: 25311862

Markey FB, Ruezinsky W, Tyagi S, Batish M (2014) Fusion FISH imaging: single-molecule detection of gene fusion transcripts in situ. PLoS One 9: e93488. PMI: 24675777

Malik M, Li L, Zhao X, Kerns RJ, Berger JM, Drlica K (2014) Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics. J Antimicrob Chemother 69: 3227-3235. PMI: 25085655

Liu TB, Xue C (2014) Fbp1-mediated ubiquitin-proteasome pathway controls Cryptococcus neoformans virulence by regulating fungal intracellular growth in macrophages. Infect Immun 82: 557-568. PMI: 24478071

Liu TB, Subbian S, Pan W, Eugenin E, Xie J, Xue C (2014) Cryptococcus inositol utilization modulates the host protective immune response during brain infection. Cell Commun Signal 12: 51. PMI: 25201772

Li SS, Gilbert PB, Tomaras GD, Kijak G, Ferrari G, Thomas R, Pyo CW, Zolla-Pazner S, Montefiori D, Liao HX, Nabel G, Pinter A, Evans DT, Gottardo R, Dai JY, Janes H, Morris D, Fong Y, Edlefsen PT, Li F, Frahm N, Alpert MD, Prentice H, Rerks-Ngarm S, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Robb ML, O'Connell RJ, Haynes BF, Michael NL, Kim JH, McElrath MJ, Geraghty DE (2014) FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial. The Journal of clinical investigation 124: 3879-3890. PMI: 25105367

Lakshminarayana SB, Tan B, Ho P, Manjunatha UH, Dartois V, Dick T, Rao S (2014) Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-tuberculosis agents. J Antimicrob Chemother: in press. PMI:

Krel M, Petraitis V, Petraitiene R, Jain MR, Zhao Y, Li H, Walsh TJ, Perlin DS (2014) Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response. Antimicrob Agents Chemother 58: 3373-3378. PMI: 24687510

Kovacs R, Gesztelyi R, Perlin DS, Kardos G, Doman M, Berenyi R, Majoros L (2014) Killing rates for caspofungin against Candida albicans after brief and continuous caspofungin exposure in the presence and absence of serum. Mycopathologia 178: 197-206. PMI: 25118874

Katragkou A, Pana ZD, Perlin DS, Kontoyiannis DP, Walsh TJ, Roilides E (2014) Exserohilum infections: review of 48 cases before the 2012 United States outbreak. Med Mycol 52: 376-386. PMI: 24682112

Jimenez-Ortigosa C, Paderu P, Motyl MR, Perlin DS (2014) Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates. Antimicrob Agents Chemother 58: 1248-1251. PMI: 24323472

Jensen RH, Justesen US, Rewes A, Perlin DS, Arendrup MC (2014) Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei. Antimicrob Agents Chemother 58: 3550-3552. PMI: 24687511

Jalah R, Kulkarni V, Patel V, Rosati M, Alicea C, Bear J, Yu L, Guan Y, Shen X, Tomaras GD, LaBranche C, Montefiori DC, Prattipati R, Pinter A, Bess J, Jr., Lifson JD, Reed SG, Sardesai NY, Venzon DJ, Valentin A, Pavlakis GN, Felber BK (2014) DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques. PLoS One 9: e91550. PMI: 24626482

Hesje CK, Drlica K, Blondeau JM (2014) Mutant prevention concentration of tigecycline for clinical isolates of Streptococcus pneumoniae and Staphylococcus aureus. J Antimicrob Chemother. PMI: 25324419

Gamaletsou MN, Daikos GL, Walsh TJ, Perlin DS, Ortigosa CJ, Psaroulaki A, Pagoni M, Argyropoulou A, Nepka M, Perivolioti E, Kotsopoulou M, Perloretzou S, Marangos M, Kofteridis D, Grammatikou M, Goukos D, Petrikkos G, Sipsas NV (2014) Breakthrough candidaemia caused by phenotypically susceptible Candida spp. in patients with haematological malignancies does not correlate with established interpretive breakpoints. Int J Antimicrob Agents. PMI: 25108876

Farmakiotis D, Shirazi F, Zhao Y, Saad PJ, Albert ND, Roilides E, Walsh TJ, Perlin DS, Kontoyiannis DP (2014) Methylprednisolone Enhances the Growth of Exserohilum rostratum In Vitro, Attenuates Spontaneous Apoptosis, and Increases Mortality Rates in Immunocompetent Drosophila Flies. J Infect Dis. PMI: 24837401

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Drlica K, Mustaev A, Towle TR, Luan G, Kerns RJ, Berger JM (2014) Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug-Gyrase-DNA Complexes Having Implications for Drug Design. ACS Chem Biol. PMI: 25310082

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Cowen LE, Sanglard D, Howard SJ, Rogers PD, Perlin DS (2014) Mechanisms of Antifungal Drug Resistance. Cold Spring Harb Perspect Med. PMI: 25384768

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Coleman T, Chen RY, Lee D, Lin K, Dodd LE, Maiello P, Via L, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, Barry CE, 3rd, Flynn J (2014) PET/CT monitoring demonstrates a therapeutic response to oxazolidinones in Mycobacterium tuberculosis infected macaques and humans. Sci Transl Med: in press. PMI:

Clancy CJ, Hao B, Shields RK, Chen L, Perlin DS, Kreiswirth BN, Nguyen MH (2014) Doripenem, Gentamicin, and Colistin, Alone and in Combinations, against Gentamicin-Susceptible, KPC-Producing Klebsiella pneumoniae Strains with Various ompK36 Genotypes. Antimicrob Agents Chemother 58: 3521-3525. PMI: 24566172

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